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Of note, the level of certainty in this recommendation is higher for the former subgroup, because some CVOTs recruited exclusively people with established CVD, while fewer events were recorded for participants with cardiovascular risk factors only in CVOTs that recruited both subgroup populations

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Specifically, GLP-1 RAs mimic the GLP-1 hormone [213] whose agonists inhibit IL-23, IL-17, and IL-22, key drivers of psoriasis and HS development [214], as well as upregulate keratinocyte migration by activating P13K/AKT pathway, which is pertinent to wound healing [215] (Fig

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