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Human studies in post-gastroenteritis and postbariatric surgery settings have observed transient increases in GLP-1 and peptide YY (PYY), potentially related to mucosal stimulation and altered gut motility [3-5]

GLP-1 has been a buzzword in health discourse over the last year with the rise of drugs like Ozempic and Wegovy, which are prescribed to people with type 2 diabetes and obesity, but have become popular as weight-loss drugs: about 1.7% of American adults were prescribed one of these semaglutide (the drugs generic name) medications in 2023

By improving the health of the brain's vasculature and reducing inflammatory responses, GLP-1R agonists may help preserve cognitive function in individuals with metabolic disorders or neurodegenerative conditions

The results add to growing evidence that the health benefits of GLP-1 drugs extend beyond the number on a scale

The side effect profiles differ

a 47% greater relative weight loss Average absolute weight lost: 22.8 kg (tirzepatide) vs