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Brain Insulin Resistance: Role in Neurodegenerative Disease and Potential for Targeting

Eli Lilly is due to submit orforglipron for Type 2 diabetes to the FDA later this year

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We specified several negative outcome controls that lack mechanistic support for or clinical evidence of a causal relation with GLP-1 receptor agonists, including benign prostatic hyperplasia, emergency department visit for superficial injury of neck or trunk, headache, and uptake of respiratory syncytial virus vaccine

That matters in chronic conditions, where treatment can last for months or even years

The corresponding author had full access to all the data in the study and was responsible for the final decision to submit the manuscript for publication