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A systematic review presented Monday at ENDO 2026, the Endocrine Society's annual meeting in Chicago, now offers some of the most comprehensive evidence to date and the answer is not what many had feared

Over the last few years, several regulatory authorities, such as the FDA and EMA, reported the incidence of mood alterations, depressive symptoms, and even suicidal thoughts with the use of GLP-1 receptor agonists during the pharmacovigilance surveillance process, which raises the issue of their psychiatric safety [13,14,15]

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Cynthia Maxwell MD, MBA, FRCSC, DABOM (Obesity Medicine), is the Medical Content Director of First Exposure, the Vice President, Medical Affairs & System Transformation and Lead Medical Executive at Womens College Hospital and Professor, Faculty of Medicine, Department of Obstetrics and Gynaecology and Division of Maternal Fetal Medicine at the University of Toronto

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