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First, address metabolic factors: hydration, protein intake, electrolyte balance, and sleep

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Diabet Med 37(12):20092018

In fact, weight gain is so common affecting 60%70% of women in middle age that its considered a symptom of menopause

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The lack of benefit with lixisenatide is likely attributable to its shorter half-life and more modest effects on glycemia and weight compared to longer-acting agonists
