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As this was a phase 2 trial, we did not define end points according to Food and Drug Administration phase 3 guidance for weight management interventions and did not counsel research participants regarding diet or lifestyle recommendations

The back of the upper arms may be used only if the injection is administered by a caregiver

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It retains much of the parent hormones anti-inflammatory character while lacking its pigment-related (melanotropic) effects

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Understanding tirzepatide's mechanism as a dual GIP and GLP-1 receptor agonist, its common side effects, and the distinction between direct pharmacological effects and indirect consequences of metabolic changes helps patients and clinicians evaluate psychological symptoms appropriately