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However, FDA inspections have identified quality control concerns, and the parent company has a documented history of regulatory issues

Since insulin therapy often indicates more advanced disease progression, greater severity, or additional comorbidities, which may lead to a higher risk of intestinal obstruction, and there was no statistically significant difference in intestinal obstruction risk between GLP-1RAs and other anti-diabetic medications (e.g., SGLT2 inhibitors, metformin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors), the observed reduction relative to insulin does not necessarily suggest a protective effect of GLP-1RAs against intestinal obstruction

They identified 70 patients who had elevated calcitonin levels during the study, of which 53% underwent additional diagnostic testing without any additional thyroid cancer diagnoses

23 Not all patients experience benefit from GLP-1RAs, with some patients experiencing increased inflammation and more flares

From unpleasant gastrointestinal side effects to serious side effects like thyroid cancer and pancreatitis, understanding the whole picture is essential