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Beyond their homeostatic functions, we show the modulatory role of the circulating gut-based peptides ghrelin and GLP-1 in enhancing and reducing reward responses, respectively

Abnormalities in circulation result in a contamination of the muscles with end-metabolites, such as lactic acid
Furthermore, Trapp emphasises the significant barrier between the bloodstream and the brain the bloodbrain barrier (BBB)

Patients with low-calorie and protein intake going into surgery may experience: slower wound healing also known as delayed wound healing or dehiscence increased inflammation or swelling higher risk of infection greater loss of lean muscle GLP-1 medications suppress appetite, which can make it easy to slip into a nutritional deficit without realizing it

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