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37 In murine models treated with GLP-1-based multi-agonists, such as GLP-1RAs/estrogen and triagonist (combining GLP-1, GIP, and glucagon), substantial improvements in metabolic function were observed, including significant reductions in body weight, fat mass, and circulating leptin levels

There is emerging evidence for benefits of metabolic surgery and three classes of glucose-lowering therapy (GLP-1 RA, SGLT2i, and GIP and GLP-1 RA) [188, 292,293,294,295,296,297,298, 316]

The results also show that the modified nanoparticles have better anti-tumor activity in vivo and in vitro against breast cancer overexpressing HER2

Verapamil, for example, is a calcium channel blocker that acts on the beta cells directly to reduce betacell apoptosis and has been shown to partially preserve Cpeptide levels in individuals with newly diagnosed T1D [108]

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