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Description
First clinical trial to investigate the efficacy and safety of combined SGLT2 inhibitor and GLP-1R agonist therapy in patients with T2DM, suggesting additive or synergistic effects on weight loss

This gives you the needed information to discuss whether they should be added to your healthcare regimen when you speak to your healthcare provider

Some patients benefit from switching to tirzepatide or the GLP-Squared dual-compound injection if semaglutide response is limited
doi: 10.1016/j.coph.2020.08.011 77 HoeBHeimbrgerSMNGasbjergLSLynggaardMBHartmannBHolstJJet al
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Online access to GLP-1 therapy removes geographical limitations that historically kept weight loss medications confined to major medical centers

Loperamide overview
