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The three receptors that retatrutide targets are the GLP-1 receptor, the GIP receptor, and the glucagon receptor

It has also been demonstrated that inhibitory GABAergic CNS GIPR + neurons are necessary for the food intake reducing effects of GIPR agonists and dual incretin co-agonists (54, 55), while excitatory glutamatergic CNS GLP-1R + neurons are necessary for the food intake reducing effects of GLP-1R agonists (71)

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It should be noted that the chills are not a common side effect for Ozempic and Wegovy, though side effects may vary from person to person

Role of p27 in prostate carcinogenesis