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Lifestyle interventions were the least effective treatment, the investigators found, producing a mean total body weight loss of 7.4% at the end of the treatment period, followed by a mean per-month weight regain of 0.14%, with participants reaching their pre-intervention weights within 4.1 years

doi: 10.1001/jama.2024.2252 21 ZakariaHAlshehhiSCaccelliMOzkanCKattanJJafaarZet al

doi: 10.2337/diacare.26.11.3116

33 Lean muscle loss, combined with prolonged inflammation, rigid tendons, impaired muscle integrity, persistent atrophy, lipid accumulation, and joint degradation, 7 , 15 will undermine musculoskeletal health, even as cardiometabolic health improves with GLP-1 agonist use

writingoriginal draft preparation, J.G.X

The available studies differ in drug type, dose, indication, timing of exposure, comparator structure, and baseline maternal metabolic risk, and the number of exposed pregnancies remains insufficient to exclude uncommon but clinically important harms (132, 133)