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One of the significant links between PCa, obesity, and metabolic disease may be due to insulin metabolism

The mechanism involves glucose-dependent insulin secretion, meaning insulin release occurs primarily when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia when used as monotherapy

Preclinical studies using native GLP-1 or GLP-1RA have provided convincing evidence of its cardioprotective benefits, while clinical trials have shown positive effects on hypertension and dyslipidemia in patients with T2DM [3]

Weghuber, D

Gough, Glucagon-like peptide-1 receptor agonists to expand the healthy lifespan: current and future potentials

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