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Research on extended GLP-1 use shows that patients who remain on therapy for 12+ months maintain 8090% of their lost weight, compared to 30% retention in those who stop after 6 months

Red flags that require immediate provider consultation: severe GI symptoms, chest pain or heart palpitations, significant mood changes, severe fatigue despite adequate sleep, any neurological symptoms, or persistent symptoms despite supplementation

This is an example of off-label use

Talk to a healthcare provider or mental health professional for medical advice before discontinuing Vyvanse

PMID: 20407008

Ongoing research aims to develop additional oral GLP-1 medications that may offer improved efficacy and convenience