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Abbreviations ACC American College of Cardiology ADA American Diabetes Association ASCVD Atherosclerotic cardiovascular disease BMI Body mass index CI Confidence interval CV Cardiovascular CVD Cardiovascular disease CVOT Cardiovascular outcomes trial DPP-4 Dipeptidyl peptidase-4 EASD European Association for the Study of Diabetes EDTA European Dialysis and Transplant Association eGFR Estimated glomerular filtration rate ERA European Renal Association ESC Europe Society of Cardiology ESRD End-stage renal disease EURECA-m European Renal and Cardiovascular Medicine FDA U.S

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& Atri, M

2018;8(1) doi: 10.1038/s41598-018-36210-9

While tirzepatide does not appear to directly cause anxiety through its pharmacological mechanism, clinicians should remain attentive to patient-reported psychological symptoms and evaluate them in the broader context of metabolic changes, lifestyle modifications, and pre-existing mental health conditions