glp 1 drugs blindness Ozempic & GLP-1s Linked to NAION, & Vision Loss? GLP-1 Weight Loss Drugs linked

doi: 10.1126/science.1092952

10.2337/db14-1577 72 ZhaiR.XuH.HuF.WuJ.KongX.SunX

Note that with this method of delivery absorption occurs predominantly in the stomach to achieve therapeutic plasma levels, and overcomes otherwise insurmountable challenges of peptide absorption related to solubility, molecular size, and enzymatic degradation in the protease-rich environment of the small intestine (Buckley et al, 2018)

F., Natural Products as Potential Sources of Antidiabetic Drugs, (2014)

This study also showed that a global KO of FFA3 results in the downregulation of GLP-1R levels in mouse islets

84 Interestingly, T2DM and IR are found to have a toxic effect on ovaries, leading to the degeneration of the gonadal tissue and the reduction in the ovarian reserve