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They are secreted by the intestine in response to nutrients and act to improve the release of insulin after a meal

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doi: 10.1016/j.annemergmed.2014.07.014 [PubMed] 25601538 Bernstein JA, Moellman JJ, Collins SP, Hart KW, Lindsell CJ

It's also worth noting that semaglutide may delay gastric emptying, which could theoretically affect the absorption of some oral medicines, though this is likely of minimal relevance to melatonin
