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A clinical challenge is that intentional weight reduction, whether through lifestyle intervention or additional treatment with OMMs, eventually levels out or plateaus. Given that clinically meaningful body weight reduction is considered 5% or greater [36, 37] and given that 1%2% change in body weight is considered a normal physiological fluctuation [38], it could be postulated that a less than 5% body weight change within 3 months following an initial intentional body weight reduction during the 60week weightloss period might reasonably reflect a clinical body weight plateau, which is the definition used in this study

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When it comes to losing weight, individuals typically gain some or all of it back after discontinuing their diet or exercise routine

Our guide on tirzepatide not working anymore covers the troubleshooting steps, but sometimes the answer is simply that a different mechanism works better for your biology

PlexusDx patients considering breastfeeding should discuss these molecular realities with their prescriber, as this evidence helps contextualize risk differently than outdated assumptions about all medications