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The concern with these medications is that the delayed gastric emptying leads to residual gastric contents, which may increase the risk of aspiration

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Pancreatic effects of liraglutide or sitagliptin in overweight patients with type 2 diabetes: a 12-week randomized, placebo-controlled trial

Apparently, GLP-1 has a protective effect on the LPS-induced RAW264.7 cell

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Compared to peptide GLP- 1 receptor agonists, orforglipron, exhibits less receptor desensitization by increasing cyclic AMP signaling [105]