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35 To overcome this rapid degradation, GLP1R agonists have been synthesized, generating supraphysiological levels of ligands that activate GLP1R 36 and eventually enhancing the natural mechanism of GLP1

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After PEG modification, it can not only bind tightly with albumin, cover the hydrolysis site of DPP-4 enzyme, but also reduce renal excretion, prolong the biological half-life and achieve the effect of long circulation

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This is an important question without a definitive clinical answer yet