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The weight loss is clinically important, as most individuals with type 2 diabetes are overweight or obese, but also because there is an unmet need for safe, effective, and durable weight loss interventions in obese individuals without diabetes.

GI side effects, along with GLP-1 medications impact on appetite, caloric intake, and food choices, can significantly affect nutrition
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Individuals achieving 5% weight loss from baseline body weight had significantly lower AF incidence (OR 0.83, 95% CI 0.780.89), whereas no significant differences were observed in those with no weight loss or weight gain (OR 1.05, 95% CI 0.971.12)

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