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There is not a single statistically rigorous human trial demonstrating successful transdermal absorption of a GLP-1 drug

By year 5 the medications cost 2-3 times more than surgery and by year 10 they cost 5 times or more

[DOI] [PubMed] [Google Scholar] 26.Pan L, Lu MP, Wang JH, Xu M, Yang SR

Another preclinical study demonstrated similar weight reduction with either a biased or balanced (non-biased) GLP-1RA and similar enhanced weight reduction with both when combined with a GIPRA [37]

Still, caution remains appropriate

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