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Research shows that somewhere between 25% and 40% of the weight lost on these medications comes from lean muscle mass

Maintain adequate hydration, monitor blood glucose levels (treating hypoglycaemia if below 4.0 mmol/L), ensure nutritional adequacy with small frequent meals, and rise slowly from sitting or lying positions

The other authors report no conflicts of interest

Metformin HCl extended-release tablets and metformin HCl immediate-release tablets have a similar extent of absorption (as measured by AUC), while peak plasma levels of metformin extended-release tablets are approximately 20% lower than those of metformin immediate-release tablets at the same dose

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Do GLP-1 medications make the microbiome less healthy