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Colonna said he usually tells patients to ground their expectations, especially at the beginning

This shift has profound implications for treatment approaches

3 Pharmacological mechanisms of tirzepatide and its applications in metabolic diseases Tirzepatide is a novel dual receptor agonist targeting both GLP-1 and GIP receptors

The substantial weight loss achieved with GLP-1 receptor agonists and dual GIP/GLP-1 agonistsapproximately 15% with semaglutide 2.4 mg (Wegovy) and up to 21% with higher doses of tirzepatide (Zepbound) in clinical trialsoccurs primarily through appetite suppression and reduced caloric intake rather than increased metabolic rate

Williams, is that the second you remove the tool (GLP-1 medication), you'll go right back to feeling hungry and craving unhealthy foods

This data underscores how Ozempic and other semaglutide drugs can cause real harms to patients