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Somatostatin analogues are able to slow the rate of gastric emptying, slow small bowel transit, inhibit the release of gastrointestinal hormones, inhibit insulin secretion and inhibit postprandial vasodilation

While Mounjaro has shown promising results, it is still a newer product with relatively limited market penetration compared to the more established options from Novo

Action Step: Aim for fiber-diverse meals as much as possible and aim for variety

This suggests that metformin-induced glucose reduction is dependent on SGLT1 expression (Zubiaga et al., 2023)

Distinguishing Mounjaro fatigue from other causes Its also possible that the fatigue you experience while on Mounjaro is not a result of the medication but rather due to other factors like lifestyle, underlying health conditions, and other treatments

Many individuals find they need to reduce their intake or change their coffee-drinking habits to align with their bodys new digestive pace