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The EM structure of Tirzepatide bound to the complete GIPR and G-proteins (Figure 3, PDB ID 7rbt, Sun et al., 2022) shows some hydrophobic and some specific polar interactions between the peptidic drug and the GIP receptor molecule

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It is therefore possible that measured platelet reactivity may vary with factors affecting plasma iCa concentration, rather than simply reflecting pharmacological resistance to antiplatelet therapy.[10, 33] Effects of citrate on coagulation and thrombus stability Citrate anticoagulation directly impairs coagulation dynamics [34] and the activation and adhesion of platelets and leukocytes in a concentration-dependent manner [35]