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Effects of Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 on the Reinstatement of Cocaine-Mediated Conditioned Place Preference in Mice

It seems in pre-clinical models that when these L-cells are exposed to perceived toxins, such as lipopolysaccharides from certain bacteria that this triggers a surge in endogenous GLP-1 which is perhaps the bodys way of using GLP-1 as an anti-inflammatory hormone or perhaps as a brake pedal on the inflammatory response in general

7274 This chronotropic effect is more pronounced with long-acting agents, 73 such as liraglutide and semaglutide, and may reflect attenuation of parasympathetic tone

The most common side effects are gastrointestinal: nausea, fullness, constipation, diarrhea, reflux, and reduced appetite

We outline new mechanistic concepts, future therapeutic opportunities, potential for differentiation from currently available medicines and areas of uncertainty requiring additional investigation

The idea is to give your body and appetite time to adjust