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While generally considered safe for most individuals, the evidence supporting their use specifically for GLP-1-related digestive symptoms remains limited and largely anecdotal

Participants on semaglutide lost an average of approximately 14.9% of body weight at 68 weeks compared with placebo

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In an animal model of depression and diabetes, however, exendin-4 led to antidepressant-like effects, which was associated with changes in microglial function 168

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Clinical trials in people with type 2 diabetes and CKD have shown potential kidney benefits with semaglutide, though this is not a licensed renal indication in the UK