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Importantly, the observed LBM reduction has not consistently translated into functional impairment, and emerging evidence suggests that GLP-1 RAs may counterbalance this effect by improving muscle quality and metabolism [21]

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Moreover, the blood-brain barrier is part of the innate immune defense against pathogens entering the CNS [3,4]

Semaglutide and Oxidative Stress Regulation The improvement of inflammation and oxidative stress by semaglutide seems to be related both by modulating SIRT1/NRF2 signaling and suppressing the activated JNK/NF-B pathways [80,152]

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15,31 Moreover, GLP-1 has been shown to improve the inflammatory milieu, vascular endothelial function, lipid profile, and cholesterol in diabetic patients