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Glycemic Efficacy, Weight Effects, and Safety of Once-Weekly Glucagon-Like Peptide-1 Receptor Agonists

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The team was hoping to hook a protein (or proteins) that, post-GLP-1 activation, had a particular chemical modification called phosphorylation

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In a cross-sectional study presented at the European Association for the Study of Diabetes annual meeting and published in Diabetes, Obesity and Metabolism , researchers surveyed adults with obesity who were using semaglutide (Ozempic/Wegovy, Novo Nordisk) or tirzepatide (Mounjaro, Eli Lilly) and asked about changes in their appetite, satiety and sensory perception after starting an incretin-based therapy

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"Upon first glance, the magnitude of effect for weight loss seemed implausible," says Eric Trexler of Duke University, who was one of the scientists who pointed out flaws in the study just weeks after it was published

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Gut Bacteria that impact GLP-1 Akkermansia muciniphila While the direct mimicry of Ozempics action by specific gut bacteria remains elusive, research has uncovered correlations between certain bacterial strains and metabolic effects akin to those induced by Ozempic

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