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Front Pharmacol 2025;16:2025

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RNA sequencing (RNA-seq) analysis Total RNA from fibroblasts was extracted using TRIzol (Takara Bio, Tokyo, Japan)

GLP-1(9-36) and GLP-1(7-36) in the concentrations of 1, 10 and 100 nM showed statistically significant inhibition of cell growth in human adipose tissue derived stem cells (hASCs), without any dose-dependent effects

While prescription GLP-1 receptor agonists have been proven to deliver results in clinical studiessome patients even losing up to 22.5% of their body weightover-the-counter options face significant scientific skepticism

Clinical studies suggest these compounds help support metabolism and appetite control, potentially by influencing hunger and satiety hormones, including GLP-1