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In 2022, global pooled analyses estimated that approximately one in eight individuals worldwide were living with obesity, encompassing 890 million adults and 160 million children and adolescents [2]

This class of medications is also associated with promoting weight loss and a low risk of hypoglycemia, and some have been shown to be associated with a significant reduction of major cardiovascular events

Statistical analyses were performed using the Student t test or ANOVA, followed by Bonferroni post tests using Prism software

Therefore, we conducted MR analysis to investigate the causal association between genetically proxied GLP-1RAs and the risk of AF, cardiac arrest, and ventricular fibrillation