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Other clinically developed small-molecule GcgR antagonists include PF-06291874, LY2409021, and LGD-6972 (RVT-1502), all of which have advanced to clinical trials but ultimately were not pursued further for the treatment of T2D or obesity due to the associated increases in circulating LDL-C, body weight, hepatic fat, and blood pressure [31]

Marini, C

Its main hormonal actions are illustrated in Fig

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These trials were randomized, double-blind, and placebo-controlled

Through personalized treatment plans, including the use of GLP-1 receptor agonists, we aim to achieve sustainable weight loss and improve overall health outcomes