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doi:10.1016/j.bbrc.2020.03.044 127

Lower inflammation

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A 24-week study to evaluate the efficacy and safety of once-weekly dulaglutide added on to glimepiride in type 2 diabetes (Award-8)

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The failure nodes include: Gut inflammation & dysbiosis Excess DPP-4mediated GLP-1 degradation Insulin resistance Impaired vagalbrain signaling Mitochondrial dysfunction in L-cells Ayurvedic translation (systems concordance) GLP-1 dysfunction maps precisely to: Agnimandya (low digestivemetabolic fire) Ama accumulation (metabolic toxins) KaphaMeda dushti (obesity, insulin resistance) PranaSamana Vata imbalance (gutbrain satiety failure) Advanced stage: Madhumeha Ayurveda predicted GLP-1 logic thousands of years ago through the AgniAmaKapha axis