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Glucagon-like peptide-1 (GLP-1) agonists are a class of medications frequently used to treat type 2 diabetes mellitus (T2DM) and obesity.[1] This class of medications assists in lowering blood sugar levels and promotes weight loss

Retatrutide, a triple agonist targeting gastric inhibitory polypeptide (GIP), GLP-1, and glucagon receptors, has achieved highly promising outcomes in its phase 2 trial [22], with weight loss up to 24%

Amyloid & tau modulation : In mouse models of AD, GLP-1 RAs reduce amyloid oligomer levels and plaque load

37 DRUG INTERACTIONS Previous trials investigating potential drug interactions with SC semaglutide have yielded few notable interactions, most likely due to the nonspecific mechanisms of metabolism seen with semaglutide

He explains that, within a one-year period, the average person can lose between 15% and 20% of their body weight

Consequently, further investigation is warranted [29]