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Oral or injectable semaglutide for type 2 diabetes in routine care Meier JJ

FDA seeks safety data for Lilly's oral GLP-1 Foundayo The FDA may have approved Eli Lilly's oral weight-loss drug Foundayo in record time, but it still needs to see more safety data including for liver and cardiovascular side effects

Understanding the difference between research grade and pharmaceutical grade peptides is essential for setting appropriate expectations about purity, potency, and consistency

As a GLP-1 receptor agonist, it works by mimicking the natural incretin hormone GLP-1 to increase insulin secretion in a glucose-dependent manner, suppress glucagon release, slow gastric emptying by approximately 35%, and reduce appetite through central nervous system signaling

IHC analyses revealed hM3D(Gq) colocalized with GLP-1 in NTS neurons that project to the VTA (Fig 3C)