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Common Digestive Changes Patients Notice As gut motility slows, some patients experience: Constipation Bloating or pressure after meals Early fullness Mild nausea Reduced hunger cues These effects are most common during dose increases or early treatment and usually improve with proper support

GLP-1 also reduces appetite and slows the passage of food out of the stomach, making you less hungry after a big meal

According to the SmPCs for these medications, the most frequently reported gastrointestinal adverse effects include nausea, vomiting, diarrhoea, constipation, abdominal pain, abdominal distension, dyspepsia and flatulence

doi: 10.3390/ijms241713381

The approved doses were studied in large trials

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