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GLP-1s may boost success rates for buprenorphine and naltrexone initiation

Gaborit B, Jacquier A, Kober F, Abdesselam I, Cuisset T, Boullu-Ciocca S, Emungania O, Alessi MC, Clement K, Bernard M, Dutour A

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The C18 fatty diacid side chain must be synthesized separately and then chemically conjugated to a specific lysine residue on the peptide backbone through a glutamic acid linker

Therefore, azithromycin is a weak inhibitor of CYP3A4, while clarithromycin and erythromycin are strong inhibitors which increase the area under the curve (AUC) value of co-administered drugs more than five-fold

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