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G protein-coupled receptors include an N-terminal extracellular domain (ECD) and a C-terminal transmembrane domain (TMD), linked to each other through a soft sequence

General guidance: Theres no need to wash out one medication before starting the other You can typically switch directly from one medication to the other Your prescriber will advise on the appropriate starting dose based on your current dose Some weight fluctuation during the transition is normal Read our full guide on how to switch providers here

Finding effective ways to manage stress, such as meditation, deep breathing exercises, or counseling, can help reduce cortisol levels and increase feelings of relaxation and well-being

When you change the timing, pay attention to any shift in how you feel, as the dip in medication levels might be slightly longer during the transition

Protect from light Store tirzepatide in its original packaging or in an opaque container

A typical approach might look like this: At month -3, you stop semaglutide and begin a basal insulin (for example, Lantus, Levemir, or Tresiba)