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For most individuals, this change is minorusually an increase of one to four beats per minute

However, it should be noted that endogenous melatonin levels decline with age 41 , and this may cause insufficient therapeutic transgene activation in vivo, potentially limiting translational applications in older populations

Neuropathic pain may impair memory by reducing GLP-1R levels in the hippocampus [45]

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who complied with the American Diabetic Association (ADA) criteria [23] for the diagnosis of prediabetes (HbA1c: 5.76.4%, or fasting glucose: 100125 mg/dL, or 2 h glucose tolerance test: 140199 mg/dL) and who had never used drugs for glycemic control

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