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Enter novel therapeutics like CCT217: By driving beige fat activation and functional thermogenesis, these agents could rapidly improve insulin sensitivity, ApoB/TG, hsCRP, hepatic fat, and microvascular functioneven before the scale moves

Currently approved GLP-1 receptor agonists in the United States include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and exenatide (Bydureon BCise)

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Dose-escalation protocols used in the Phase 2 trial began at sub-therapeutic doses and escalated over 8-16 weeks, which is believed to minimize gastrointestinal adverse events

Both medications can also cause reactions at the injection site