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In 2004, it was reported that subcutaneous (s.c.) administration of the BPC 157 peptide to rats (10 g/kg/day for 7 days) resulted in brain region-specific increases in serotonin synthesis [99], as determined by the precise alpha-[ 14 C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method

Several human and animal studies have demonstrated the therapeutic effects of GLP-1 receptor agonist in slowing the progression of NAFLD

However, healthcare providers often monitor patients closely when they are taking multiple medications that could impact weight

29 In this context, GLP-1R agonists represent an intermediate therapeutic option, more effective than lifestyle or other pharmacological approaches, yet less invasive than surgical procedures

In this context, portfolio strategies become more visible during this era, as leading players seek to position multiple assets across induction, maintenance, label expansion and distinct patient segments in an increasingly crowded market

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