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Int J Obes 2020

Overall, these results are in line with enhanced GLP-2R action, previously shown to increase villus length by promoting intestinal cell proliferation and inhibiting apoptosis at the villus tip 17

The group tracked Truveta data on more than 41,000 overweight or obese patients first given tirzepatide or semaglutide from May 2022 to September 2023

[5] Accessibility : Tirzepatide is FDA-approved and widely available, while Mazdutide remains in clinical trials

The STEP (Semaglutide Treatment Effect in People with obesity) trials, which included over 4,500 participants, showed that semaglutide 2.4 mg weekly resulted in mean weight loss of 12.4% to 15.3% of initial body weight over 68 weeks, compared to 2.4% to 3.2% with placebo

GLP-1 patches are an emerging technology being studied as an alternative to injectable GLP-1 receptor agonists, which are medications commonly prescribed for type 2 diabetes and weight management