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It was the first of several DPP-4 inhibitors introduced for treating type 2 diabetes

The profile of a typical heart disease patient has shifted over the past 30 years from the hypertensive, chain-smoking, type A personality to someone with overweight or obesity and concomitant diabetes

Anagliptin in the treatment of type 2 diabetes: Safety, efficacy, and patient acceptability

These risk differences might be explained by additional mechanisms beyond the actions of GLP-1 RAs on vasculature, including the chronotropic effects of GLP-1 RAs which may blunt cardiac protection ( Unstable angina pectoris: An umbrella review of meta-analyses of RCTs including 56,004 patients with diabetes, prediabetes, and at high risk of diabetes, found no association between GLP-1 RAs and the risk of uAP (RR = 1.06, 95%CI = 0.931.21) when compared to placebo (Zhu et al., 2020)

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If you accidentally use a TB syringe thinking the markings are units, you will inject 10 times the intended dose