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Chronic kidney disease is also becoming strategically important, especially as semaglutide data and regulatory momentum support broader cardiometabolic use

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Visceral adiposity, which leads to insulin resistance, is the putative mechanism in the development of diabesity, leading to insulin dependent Type 2 diabetes.2 The GLP-1 journey did not stop at treating Type 2 diabetes alone but has moved on to treating obesity, typically using higher dosing. THE RISE OF GLP-1 AGONISTS (INCRETIN MIMETICS) Along with newer classes of oral drugs for treating Type 2 diabetes such as DPP-IV (dipeptidyl peptidase-4) inhibitors and SGLT-2 (sodium-glucose co-transporter-2) inhibitors, the GLP-1 (glucagon-like peptide-1) receptor agonist drug class is being prescribed to combat Type 2 diabetes and to slow patient progression towards insulin dependency