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Heres what the research and my clinical experience reveal: Semaglutide is a well-established option with: Weekly injections Proven safety profile Average weight loss of 15-20% of body weight Effective appetite suppression Improvements in cardiovascular health markers Tirzepatide offers: Weekly injections Potentially greater weight loss (16-22.5% of body weight) Dual-action mechanism Similar side effect profile to semaglutide Enhanced metabolic benefits In a recent head-to-head trial , tirzepatide demonstrated superior weight loss compared to semaglutide, with participants losing an average of 20.2% versus 13.7% of their body weight at 72 weeks

Thanks to a small injection (or now pill) they have the opportunity to do things they have never been able to do before, enjoy the small moments of life without judgement or shame

BDNF, brain-derived neurotrophic factor

[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Pretibial myxedema: pathophysiology and treatment options

For those of us with complex, multi-system conditions like MCAS or heritable connective tissue disorders, it may translate into improvements across multiple areas of dysfunction