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injections of 100 nmol kg 1 GLP-1MK-801, 10 nmol kg 1 semaglutide or vehicle (isotonic saline) based on baseline running wheel distance measurements, such that each group had similar average running wheel distances at the day of study initiation

A patient with favorable GLP1R signaling predispositions may achieve satiety and weight loss at lower doses, while another individual may require higher concentrations despite similar baseline characteristics

Short-term users faced higher risks of each outcome compared to long-term users

Semaglutide (Ozempic, Wegovy, and Rybelsus) is a popular GLP-1 agonist that has gained popularity due to its effectiveness in promoting weight loss and managing type 2 diabetes

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