weight regain after stopping glp-1 agonists cessation of medication for weight management: systematic review and meta-analysis GLP-1 Drugs: Bridging Satiety, Nutrition,
Description
If using adjunctive treatments, either metformin or topiramate are good options for weight loss that may also benefit metabolic parameters (glucose/insulin, lipids) or symptoms, respectively.

However, some clinical evidences suggest that GLP-1RA therapy could potentially increase the risk of colorectal cancer in a subset of patients [38]

As of the first week of September, that number has shot up to 869

Left unchecked, it can cause fatty deposits to build up in artery walls, raising the risk of heart attack, stroke and other cardiovascular disease

That last part is crucial
Abstract Glucagon-like peptide-1 receptor agonists are a class of drugs that mimic a natural incretin hormone released by the intestine after meals, and they are well-suited for treating type 2 diabetes