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Description
This biological framework supports the hypothesis that androgen status may influence skeletal muscle resilience during sustained weight reduction, as illustrated in Figure 2
p = 0.0001) (287)

ETD, estimated treatment difference

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Importantly, no studies have yet addressed long-term neurodevelopmental outcomes in exposed offspring, a critical gap given the rising use of these agents among reproductive-age women

These were patients on medications, so a 9.5 mmHg improvement was more than was predicted. In terms of side effects, one-quarter of people taking tirzepatide in both studies experienced gastrointestinal side effects like nausea, vomiting, and constipation, which often diminished over time
