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This occurs through the release of decorin, which binds to the AGER receptor on macrophages, driving immune activation (230)

Chief among these are limitations in BBB permeability, the reliance on male-dominant animal models, the absence of standardized behavioral endpoints, and the variability in CNS penetrance across GLP-1 analogues

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The Pendulum GLP-1 Probiotic and similar products often include these prebiotic fibers as part of their formulations